Differenial_expression_data_of_four_pathogen_project

The mouse pathogen Citrobacter rodentium has been used to model EPEC and EHEC infection in vivo. Studies are addressing the critical role of the gut microbiome in host responses to these food-borne infections, however the comparability of data across laboratories is often negatively affected by variations in different research facilities.

In this study, we used the standardized OligoMM12 microbiota mouse model for studying these pathogens. We provide evidence of robust colonization and significant pathological changes in OligoMM12 mice following infection with these pathogens. Moreover, we offer insights into pathogen-specific host responses and metabolite signatures, highlighting the advantages of a standardized mouse model for direct comparisons of factors influencing the pathogenesis of major food-borne pathogens.