Omics · study · 2026
Gene expression alteration in mouse articular chondrocytes by 25-hydroxycholesterol, 25-hydroxycholesterol-3-sulfate and GW3965 treatment
Listed in NCBI GEO
Previous studies have demonstrated that 25-hydroxycholesterol (25HC), which is involved in the initiation and progression of osteoarthritis (OA), can be sulfated by SULT2B1 to produce 25-hydroxycholesterol-3-sulfate (25HC3S).
Description
Given this background, this study aims to investigate whether 25HC3S and 25HC have different functional effects on articular chondrocytes. Additionally, since 25HC has been proven to be an endogenous ligand of liver X receptor (LXR), this study also compares the effects elicited by the LXR agonist GW3965 on articular chondrocytes to provide insights into whether 25HC and its sulfated derivative, 25HC3S, exert distinct influences on the LXR signaling pathway.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE283nnn/GSE283360 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE283360 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1193519 ncbi.nlm.nih.gov/bioproject/PRJNA1193519 ↗
project · from NCBI GEO
- PubMed 42156738 pubmed.ncbi.nlm.nih.gov/42156738 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE283360 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |