Data · dataset · 2026
Investigating molecular vulnerabilities in early-stage disseminating colorectal cancer
Listed in ZivaHub and Deakin Research Online and DMU Figshare and UCL Research Data Repository — shown once because both records carry DOI 10.17034/32632833.v1
Early detection of colorectal cancer (CRC) is critical, as > 95% of people diagnosed at stage I will survive.
Description
While stage I CRC represents a small proportion of symptomatic CRC cases, 42-48% of cases now diagnosed within the bowel cancer screening programme are at stage I. Despite this good prognosis, a small proportion of the earliest colorectal tumours go on to develop distant metastasis. This is contrary to the classical “linear progression” model of metastasis and suggests that these tumours harbour an early dissemination biology at initiation, rather than the sequential gain of aggressive traits over time.
Using a cohort enriched for these highly aggressive T1 tumours, this study aimed to identify and characterise the biology underpinning aggressive early disseminating tumours in CRC.<br>
Links
Where it is published
- DOI doi.org/10.17034/32632833.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Cancer · Cancer · Cancer · Cancer · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health
- Inferred from text
- Oncology and carcinogenesis 73%
Provenance · 4 source records, 17 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32632833 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32632833 | 13 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32632833 | 13 d ago | JSON v1 |
| UCL Research Data Repository | oai:figshare.com:article/32632833 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[disease].local:disease:cancer | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['cancer'] |
| concepts[disease].local:disease:cancer | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['cancer'] |
| concepts[disease].local:disease:cancer | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['cancer'] |
| concepts[disease].local:disease:cancer | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['cancer'] |
| concepts[field].anzsrc:group:3211 | enrichment · zivahub uct ac za | taxonomy-embedding@1.1.0 | title+keywords+description (73%) |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |