Supplementary file 1_Altered resting-state brain function in diabetic retinopathy: a meta-analysis of combined transcriptome-neuroimaging study.docx

Previous studies have reported abnormal brain functional alterations in patients with diabetic retinopathy (DR), which may be associated with cognitive impairment in diabetes; however, the molecular correlates of these brain alterations remain poorly understood.</p>Methods<p>In this study, we performed a coordinate-based neuroimaging meta-analysis to identify convergent resting-state brain functional alterations in patients with DR.

By integrating the meta-analytic imaging phenotype with gene-expression data from the Allen Human Brain Atlas, we further conducted spatial transcriptomic -neuroimaging analyses to identify genes whose normative expression patterns were spatially associated with DR-related brain functional alterations.</p>Results<p>The meta-analysis revealed relatively increased resting-state functional measures in the left cerebellum and corpus callosum, whereas relatively decreased measures were observed in the left calcarine fissure, left middle occipital gyrus, two clusters in the right postcentral gyrus, right anterior cingulate cortex, and right middle temporal gyrus.