Alberta Childhood COVID-19 Cohort [AB3C, study data contributed to the CITF Databank]

Aims of the original study: The AB3C study aimed to determine how many children with and without known COVID-19 infections have made an immune response (blood antibodies) over time, and the epidemiologic and immunological correlates of infection risk and COVID disease severity.

Methods

Parents were invited to enroll their child (less that 18 years) in the study if they lived in or near Calgary, AB. They were enrolled as single-visit or longitudinal participants. In addition to questionnaire items, at each visit (6 months apart) past COVID infection status was ascertained (priority to PCR result) and a blood sample drawn for serology.

IgG antibodies to SARS-CoV-2 nucleocapsid protein and receptor binding domain of the spike were measured. Summary of the contributed data: The dataset includes 1030 participants who completed a baseline visit between August and November 2020 and provided at least one blood sample. 94% of participants were followed longitudinally up to 2 years (median: 19 months). Available variables include data for the following areas of information: demographics (age, sex, race-ethnicity and indigeneity, FSA), chronic health conditions, and BMI at baseline; acute COVID infection evidence, SARS-CoV-2 vaccination, and serology over time.