Omics · study · 2026
Evolution of CCNB1IP1 regulating emergence and increase of cortical folding in primates
Listed in NCBI GEO
Cortical expansion and folding have gradually increased during primate evolution, reaching the highest in the human brain.
Description
Indeed, cortical folding has a concerted relationship with neocortex expansion, underlying evolution of human cognitive functions. However, molecular mechanisms underlying concerted evolution remain largely unknown.
Here, using Chinese tree shrew as an outgroup of primate, we identify the Cyclin B1 Interacting Protein 1 gene CCNB1IP1 (also named HEI10) as a key regulator of cortically concerted evolution. CCNB1IP1 has acquired brain expression in primates, and is highly expressed in human neuronal progenitor cells. The expression of CCNB1IP1 has gradually increased along primate brain evolution, coinciding with the increase of cortical size and folding.
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Mechanistically, we elucidated that overexpression of CCNB1IP1, leading to a decrease of G1 duration, and subsequently causes an increase in basal progenitors and neurons. Furthermore, we generated a novel CCNB1IP1 knock-in mouse model and provide confirmation that CCNB1IP1 can induce cortical folding in otherwise smooth mouse brain. Moreover, the CCNB1IP1 knock-in mouse model exhibited traits associated with enhanced learning and memory abilities.
Together, our study reveals how the changes in CCNB1IP1 expression may have contributed to the increase of cortical size and folding during human brain evolution.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE247nnn/GSE247966 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE247966 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1041315 ncbi.nlm.nih.gov/bioproject/PRJNA1041315 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Evolutionary biology 72%
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE247966 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3104 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (72%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |