Omics · study · 2026
Early Intervention of the PKC-Hippo Signaling Alleviates Post-Traumatic Osteoarthritis
Listed in NCBI GEO
Post-traumatic osteoarthritis (PTOA) is a progressive joint disease triggered by mechanical injury and characterized by inflammation and cartilage degradation.
Description
The Hippo signaling pathway and its upstream regulator PKCζ have emerged as key modulators of mechano-inflammatory responses in chondrocytes. This study aimed to investigate the dynamic regulation of the PKC-Hippo signaling axis following joint injury and to evaluate the therapeutic potential of targeting this pathway in early PTOA.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE294nnn/GSE294777 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE294777 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1249407 ncbi.nlm.nih.gov/bioproject/PRJNA1249407 ↗
project · from NCBI GEO
- PubMed 42620708 pubmed.ncbi.nlm.nih.gov/42620708 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE294777 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |