New insights of molecular regulatory mechanisms of intestinal and systemic response to Aeromonas veronii infection in grass carp

However, frequent outbreaks of bacterial diseases caused by Aeromonas ssp. have led to huge economic losses in grass carp farming. Various omics technologies have been used to study the response of grass carp to these pathogens.

For instance, the transcriptional profile of the spleen from grass carp challenged with A. hydrophila, which revealed significant enrichment of gene clusters, including phagocytosis, complement system, cytokines, antigen processing and presentation, pattern recognition receptors, cell adhesion molecules, apoptosis, and antioxidant enzymes. Furthermore, a large number of differentially expressed genes related to inflammation were identified in the intestinal transcriptome of grass carp infected with A. hydrophila.