Table 1_Depression and medication adherence among chronic hepatitis B patients receiving resilience-based care versus standard care during antiviral therapy: a retrospective cohort study.docx

To account for potential confounding by indication and baseline imbalances, multivariable linear, logistic, and Poisson regression models were used, with adjusted effect estimates and 95% confidence intervals reported.</p>Results<p>At the 6-month follow-up, the observation group had lower depression scores (6.78 ± 3.45 vs. 10.23 ± 4.12), higher MPR (0.92 ± 0.08 vs. 0.78 ± 0.15), and higher resilience scores (32.45 ± 5.67 vs. 26.78 ± 6.34).

Virological response (85.0% vs. 70.0%; adjusted OR 2.46, 95% CI 1.35 to 4.48) and ALT normalization (80.0% vs. 65.0%; adjusted OR 2.01, 95% CI 1.10 to 3.67) were more frequent in the observation group. SF-36 physical and mental component scores were also higher in the observation group. Adverse event incidence was similar between groups.

The observation group had fewer unplanned outpatient visits (P = 0.045), and Poisson regression confirmed fewer outpatient visits in the observation group (adjusted rate ratio 0.72, 95% CI 0.56 to 0.93). However, because allocation was non-randomized, these associations may be affected by self-selection and residual confounding.</p>Conclusion<p>In this retrospective cohort study, receiving a resilience-focused program in addition to standard care was associated with lower depressive symptoms, better medication adherence, and more favorable virological and biochemical outcomes in patients with CHB.</p>