Omics · study · 2026
Drug-seq analysis of adult T-cell leukemia cells treated with fluorouracil and bleomycin
Listed in NCBI GEO
Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy that develops in a subset of individuals infected with human T-lymphotropic virus type 1 (HTLV-1) and is characterized by marked chemoresistance and frequent relapse.
Description
HTLV-1 preferentially infects CD4⁺ T cells, which constitute the main malignant population in ATL. We evaluated transcriptomic perturbations in CD4⁺ T cells from five ATL patients, three healthy donors, and two ATL cell lines following 48-hour treatment with the chemotherapeutic agents fluorouracil and bleomycin sulfate.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319793 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319793 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1425097 ncbi.nlm.nih.gov/bioproject/PRJNA1425097 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE319793 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |