Omics · study · 2026
Pregnane X Receptor-Mediated Liver Growth: A Controlled Clinical Study In Humans And Identification Of The Role Of Akt-Mtor-Pathway In Mouse [RNA-Seq 2]
Listed in NCBI GEO
Pregnane X receptor (PXR) is a nuclear receptor acting as a master xenobiotic receptor for many exogenous chemicals.
Description
Activation of PXR has been linked to liver growth in mice. Pxr-/- mice were transduced with adenovirus carrying either murine PXR or green fluorescent protein(GFP) as a control and both groups were treated with pregnenolone-16α-carbonitrile (PCN) for 1 to 4 days.
In this setup, activation of PXR with PCN significantly increased liver size in male mice and this growth was associated with the activation of proliferative AKT-mTOR pathway.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297893 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297893 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1266687 ncbi.nlm.nih.gov/bioproject/PRJNA1266687 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE297893 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |