Multicenter Contrast-Enhanced CT Dataset for Digital Twin-Guided Immunotherapy Optimization in Unresectable Hepatocellular Carcinoma

This dataset contains 1,010 baseline contrast-enhanced CT scans from a multicenter cohort of patients with unresectable hepatocellular carcinoma undergoing immune checkpoint inhibitor-based combination therapy.The cohort was collected from multiple Chinese medical centers and includes patients receiving either immune checkpoint inhibitors plus molecular targeted therapy or immune checkpoint inhibitors plus molecular targeted therapy combined with transarterial chemoembolization.

CT scans were acquired within two weeks before treatment initiation and were used together with clinical variables, tumor characteristics, treatment information, and survival outcomes to develop and validate an AI-powered multimodal fusion digital twin system for individualized survival prediction and treatment optimization.