Omics · study · 2026
Erythroid ACKR1 deficiency aggravates immune-mediated kidney disease
Listed in NCBI GEO
Single nucleotide polymorphisms (SNP) of atypical chemokine receptor 1 (ACKR1) gene encode human Duffy Antigen blood groups.
Description
The majority of individuals of West African ancestry carry a SNP in the promoter region of the ACKR1 that disrupts its transcription in erythroid cells only, but not in venular endothelial cells, leading to an “erythroid silent”, FyBES Duffy phenotype.Irradiation bone marrow ACKR1 chimeric mice lacking erythroid ACKR1 (KO->WT) showed increased disease activity and fibrosis after induction of nephrotoxic serum nephritis (NTSN), as compared to their respective controls (WT->WT).
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE276nnn/GSE276017 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE276017 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1154286 ncbi.nlm.nih.gov/bioproject/PRJNA1154286 ↗
project · from NCBI GEO
- PubMed 40960880 pubmed.ncbi.nlm.nih.gov/40960880 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE276017 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |