Supplementary file 1_Risk factors for recurrence after initial transurethral resection of bladder tumor in patients with non–muscle-invasive bladder cancer.docx

Multiple tumors were associated with higher recurrence odds and hazard (adjusted odds ratio [OR], 1.88; 95% confidence interval [CI], 1.27–2.78; adjusted hazard ratio [HR], 1.62; 95% CI, 1.25–2.10). Higher recurrence odds and hazards were also associated with increasing tumor diameter, T1 or primary CIS, high-grade pathology, concomitant CIS, and higher baseline neutrophil-to-lymphocyte ratio. Maintenance intravesical therapy was inversely associated with recurrence (adjusted OR, 0.49; 95% CI, 0.34–0.72; adjusted HR, 0.62; 95% CI, 0.47–0.81).

Estimated RFS rates were 81.5%, 63.8%, and 54.1% at 1, 3, and 5 years, respectively. The bootstrap-corrected area under the curve was 0.769 for the logistic model, and the bootstrap-corrected Harrell’s C-index was 0.739 for the Cox model.</p>Conclusions<p>Recurrence after initial TURBT was associated with greater tumor burden, adverse pathological characteristics, concomitant CIS, and higher baseline neutrophil-to-lymphocyte ratio.

Maintenance intravesical therapy showed an inverse observational association with recurrence. These routinely available factors may support postoperative risk stratification and risk-adapted surveillance.</p>