Omics · study · 2026
RNA-seq profiling of post-hypoxic head and neck cancer cell lines
Listed in NCBI GEO
Hypoxia is an important cause of radiotherapy resistance in head and neck squamous cell carcinoma (HNSCC).
Description
To investigate the transcriptional expression associated with post-hypoxic survival, we performed RNA-seq profiling of HPV-negative (FADU) and HPV-positive (SCC154) hypoxia-fate-mapped cell lines, hereafter called FADU-hfm and SCC154-hfm. Non-hypoxic (DsRed-positive) and post-hypoxic (GFP-positive) cells were sorted from 3D hfm-spheroids using fluorescence-activated cell sorting (FACS) and analyzed under normoxic conditions.
The resulting dataset provides gene expression profiles of non-hypoxic and post-hypoxic cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319374 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319374 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1423175 ncbi.nlm.nih.gov/bioproject/PRJNA1423175 ↗
project · from NCBI GEO
- PubMed 41972846 pubmed.ncbi.nlm.nih.gov/41972846 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE319374 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |