Table · dataset · 2026
Supplementary file 1_Shift work disrupts Immune regulation of the transcriptome in hospital nurses.docx
Listed in figshare and Loughborough Research Repository — shown once because both records carry DOI 10.3389/fpubh.2026.1859265.s001
Introduction<p>Shift work, especially night shifts in medicine, disrupts nurses‘ circadian rhythms, potentially causing immune dysregulation and health risks, with significant economic and medical burdens.
Description
The molecular mechanisms of shift work-related immune disorders are understudied. This research analyzes transcriptomes of nurses' peripheral blood mononuclear cells (PBMCs) from different shifts to identify key differentially expressed genes and explore their roles in immune regulation.</p>Method<p>This study combined bioinformatics and animal experiments, analyzing the GSE122541 dataset for DEGs in day and night shift nurses' PBMCs.
WGCNA identified core gene modules linked to night shift. Protein interaction networks were analyzed for hub genes, with expression validated in a circadian rhythm disorder mouse model.</p>Results<p>The analysis found many differentially expressed genes in night shift nurses' PBMCs, mainly in immune pathways like T-cell receptor signaling and differentiation. WGCNA identified gene modules linked to night shifts, intersecting to reveal 8 candidate hub genes, with TRIM22 and JAK1 core in the network and downregulated in nurses.
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Mouse models showed Trim22 and Jak1 also decreased during nighttime activity, indicating their downregulation is a common trait in circadian rhythm disorders, involving interferon-γ and NF-κB immune signaling.</p>Conclusion<p>This study shows that night shift work disrupts circadian rhythm and downregulates immune genes like TRIM22 and JAK1 in PBMCs. These genes may link shift work to immune imbalance, are potentially associated with IFN-γ and NF-κB pathways, offering potential targets for understanding shift work's health risks and developing interventions.</p>
Links
Where it is published
- DOI doi.org/10.3389/fpubh.2026.1859265.s001 ↗
DOI / persistent id · from figshare com
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare com
Topics
- From keywords
- Astronomy & Astrophysics · Chemistry · Chemistry · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Humanities · Humanities · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science
Provenance · 2 source records, 28 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| figshare | oai:figshare.com:article/33962161 | 12 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/33962161 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| description | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/description |
| license | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/rights |
| publication_date | source · figshare com | connector:figshare_com@1.0.0 | |
| title | source · figshare com | connector:figshare_com@1.0.0 | /metadata/dc/title |