Table 1_Nerve block or wound infiltration with liposomal bupivacaine for postoperative pain management in open orthopedic surgery: a meta-analysis of 38 randomized controlled trials involving 3,389 patients.docx

The results demonstrated that there was statistical significance in pain intensity scores on POD2 [SMD = −0.25, 95% CI (−0.49 to −0.02)] and a trend toward statistical significance on postoperative day 1 (POD1) [SMD = −0.17, 95% CI (−0.35 to 0.00)] between the two groups. However, no statistical differences in pain scores on POD0, POD3, opioid consumption (total, POD1, POD2, POD3), adverse events, patient satisfaction, and the length of hospital stay.</p>Conclusion<p>Compared to conventional medications, LB does not demonstrate a significant advantage in perioperative pain management, nor does it significantly reduce opioid consumption.

Further high-quality RCTs are required to confirm these findings and greater attention should be given to the long-term safety of LB to ensure its reliability for practical use.</p>