DATA-Controlling T Cell-Tumor Cell Interaction with A Biomimetic Physical Barrier for Cancer Immunotherapy

This study demonstrates a therapeutic strategy based on a physical barrier created by a hydrogel, which establishes a protective zone for T cells within the tumor microenvironment. This approach enables T cell accumulation and delays T cell exhaustion process, effectively suppressing tumor growth.

When combined with OX40 antibody therapy, this strategy achieves a 50% tumor cure rate. These findings provide a perspective for cancer treatment, bridging materials science and immunology to address critical challenges in immunotherapy.