Omics · study · 2026
The Effects of Refined Carbohydrates on Systemic Immunity: Results from a Randomized Controlled Feeding Trial
Listed in NCBI GEO
Objective To explore the effects of three diets differing in amount and type of refined carbohydrates on peripheral immunity.
Description
Methods
After a weight loss of 15% with a very low carbohydrate diet (VLCD), participants were randomized to isocaloric diets: VLCD diet; high carbohydrate diet with high starch content (HC-Starch); or high carbohydrate diet with high sugar content (HC-Sugar). Changes in peripheral immunity were assessed using a multimodal analyses before randomization and after 10 weeks of diet. Results Multiplexed cytokine analysis shows increased adipsin in HC-Starch and decreased adiponectin in HC-Sugar.
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Transcriptomics analysis shows upregulation of immune and metabolic pathways with HC-Starch, but reductions with HC-Sugar. CyTOF revealed significant shifts in NK cell populations and increased inflammatory markers in neutrophils and monocytes following consumption of HC-Starch. Conclusions Consumption of refined starch following weight loss on a VLCD increases circulating markers of immune activity, whereas sugar consumption reduces these markers.
Keywords: dietary nutrients, immunity, refined starch, added sugar, VLCD, cytokines, gene expression, CyTOF, inflammation, immune cells. ClinicalTrials.gov registration: NCT03394664
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE278nnn/GSE278745 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE278745 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1168553 ncbi.nlm.nih.gov/bioproject/PRJNA1168553 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Food sciences 71%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE278745 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3006 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (71%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |