Data for: ASC oligomer favors caspase-1 CARD domain recruitment after intracellular potassium efflux

Low concentrations of intracellular K+are associated with the specific oligomerization and activation of the NLRP3 inflammasome, a type of inflammasome involved in sterile inflammation. After NLRP3 oligomerization, ASC protein binds and forms oligomeric filaments that culminate in large protein complexes named ASC specks.

ASC specks are also initiated from different inflammasome scaffolds, such as AIM2, NLRC4 or Pyrin. ASC oligomers recruit caspase-1 and then induce its activation through interactions between their respective caspase activation and recruitment domains (CARD). So far ASC oligomerization and caspase-1 activation are K+-independent processes.