Supplementary file 1_Comparative associations of immune-inflammatory, immune-lipid, and metabolic composite indices with hyperuricemia among Chinese adults with glycemic abnormalities: a health examination-based cross-sectional study.docx

In primary multivariable-adjusted model, immune–lipid indices, including WHR, NHR, LHR, MHR, and PHR, were all positively associated with HUA. Among metabolic indices, AIP showed the strongest association with HUA, followed by TyG, METS-IR, and CHG, whereas RC and NHHR were not significantly associated with HUA in the primary multivariable-adjusted model. Among traditional immune-inflammatory indices, SIRI and PIV remained positively associated with HUA, while PLR showed an inverse association and NLR, MLR, and SII were not significant.

Restricted cubic spline analyses revealed nonlinear and threshold-dependent associations for several immune–lipid and metabolic indices, with HUA odds increasing at lower-to-moderate levels and then tending to plateau or attenuate at higher levels. Among demographic and anthropometric characteristics, sex, age, and BMI were the most prominent effect modifiers, with generally stronger associations observed in women, participants aged <60 years, and those with BMI <24 kg/m².</p>Conclusions<p>Among Chinese adults with glycemic abnormalities, all three categories of indices were associated with HUA.

Among the metabolic composite indices, AIP showed the strongest association with HUA, while TyG, METS-IR, and CHG were also positively associated with HUA. Immune–lipid indices, including WHR, NHR, LHR, MHR, and PHR, showed consistent positive associations with HUA, whereas among conventional immune-inflammatory indicators, PLR, PIV, and SIRI were associated with HUA.</p>