Omics · study · 2026
Transcriptional regulation of APE1-redox Axis in Esophageal adenocarcinoma
Listed in NCBI GEO
Apurinic/apyrimidinic endonuclease 1 (APE1/Ref-1) plays an essential role in ROS-sensitive transcriptional regulation in esophageal adenocarcinoma (EAC).
Description
While the redox function of APE1 is known to modulate the activity of multiple transcription factors, its global downstream targets in EAC remain to be fully characterized. This study investigates APE1-redox-dependent transcriptional regulation by targeting OE33 cells with the APE1-redox-specific inhibitor, APX2009, to map the underlying gene expression networks.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342315 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342315 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1507346 ncbi.nlm.nih.gov/bioproject/PRJNA1507346 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE342315 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |