Dataset on 7-day Isoproterenol treatment in female mice

This dataset originates from an experimental study investigating the effects of β-AR hyperactivation on PVAT in female mice. Three-month-old female mice were subjected to 7-day treatment with isoproterenol (ISO), a non-selective β-AR agonist, or vehicle (VEH).

Evaluated parameters included body composition, vascular reactivity, PVAT mRNA and DHE fluorescence analyses. The dataset encompasses initial and final body weight, organ and adipose tissue weights, concentration-response curves in aortic rings with and without PVAT using agonists such as phenylephrine, acetylcholine, and isoproterenol, quantification of β-AR expression, estrogen receptors, brown adipose tissue (BAT) markers, antioxidant and pro-oxidant enzymes, as well as nitric oxide synthase isoforms (eNOS and iNOS), and assessment of reactive oxygen species in PVAT via DHE.