Omics · study · 2026
The role of Su(Hw) in recruiting the architectural protein Pita to chromatin
Listed in NCBI GEO
The architectural C2H2 proteins Pita and Su(Hw) significantly contribute to the formation of active promoters and insulators in Drosophila.
Description
At the majority of regulatory elements, these proteins bind and function independently of each other. We have shown that Pita and Su(Hw) can be present in the same complex in embryonic extract, yet they do not interact directly with each other.
We identified 49 genomic sites where Pita binding is completely dependent on Su(Hw). These sites lack the co-localization with CP190, which typically binds to both Pita and Su(Hw). Such sites are also characterized by a strong, consensus-like motif for the Su(Hw) protein and, conversely, a relatively degenerate motif for Pita.
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The obtained results suggest a novel mechanism for recruiting the architectural protein Pita to regulatory elements through complex formation with Su(Hw), which determines chromatin binding.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE312nnn/GSE312693 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE312693 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1375722 ncbi.nlm.nih.gov/bioproject/PRJNA1375722 ↗
project · from NCBI GEO
Topics
- Stated by source
- Drosophila melanogaster · Genome binding/occupancy profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Genetics 69%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE312693 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].anzsrc:group:3105 | enrichment · NCBI GEO | taxonomy-embedding@1.1.0 | title+keywords+description (69%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:7227 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |