Omics · study · 2026
In vivo-based CRISPR screen identifies ZC3H12C as a mediator of CAR-T cell dysfunction in solid tumors
Listed in NCBI GEO
In this work, we have sought to develop an in vivo model of xenograft tumors that recapitulates disease recurrence in absence of antigen modulation, to study the T cell-intrinsic mechanisms that give rise to CAR-T cell dysfunction.
Description
We have developed an in vivo model in which CAR-T cell become dysfunctional. We isolated tumor infiltrating CAR-T cells after long exposure to tumors and studied the transcriptome.
Using this newly generated knowledge, we have identified gene candidates whose genetic deletion could enhance CAR-T antitumor effect in a model of solid tumors.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE309nnn/GSE309402 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE309402 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1336011 ncbi.nlm.nih.gov/bioproject/PRJNA1336011 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE309402 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |