Omics · study · 2026
Chaperone condensates buffer the heat shock response against pleiotropic inputs [RNA-seq]
Listed in NCBI GEO
RNA-seq of Saccharomyces cerevisiae profiling the heat shock response (HSR) across chemically distinct stresses and upon acute nuclear depletion of the co-chaperone Sis1.
Description
Wild-type cells were profiled unstressed and under heat shock, sodium arsenite, azetidine-2-carboxylic acid (AZC), diazaborine (DZA), and hyperosmotic NaCl, each with and without cycloheximide (CHX) to test translation-dependence. In parallel, a rapamycin-resistant Sis1 anchor-away strain was profiled with and without rapamycin across the same stresses.
Only heat shock and, weakly, arsenite induce HSR target genes; nuclear Sis1 buffers HSR output under sub-saturating stress.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE339nnn/GSE339192 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE339192 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1497957 ncbi.nlm.nih.gov/bioproject/PRJNA1497957 ↗
project · from NCBI GEO
- PubMed 42619928 pubmed.ncbi.nlm.nih.gov/42619928 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Saccharomyces cerevisiae
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE339192 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:4932 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |