Excel · study · 2026
Transcriptional profiling of Mouse Epidermis Treated with DMBA and TPA
Listed in NCBI GEO
We compared expressions of cancer-related genes (tumor suppressor genes and oncogenes) in the skin epidermis between FVB mice treated with DMBA/TPA and control animals.
Description
Bulk RNA-seq analyses revealed that in contrast to control animals, epidermis of mice treated with DMBA is characterized by upregulation of the genes enriched for immune response pathways, whereas downregulated genes were involved in the control of extracellular matrix remodeling and wound healing.
In mouse epidermis treated by DMBA/TPA, transcriptional response to DMBA/TPA at the pre-tumor stage was accompanied by upregulation of the genes controlling epidermal differentiation, oncogenes including the components of Wnt signaling pathway, as well as of selected tumor suppressor genes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334587 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334587 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1475985 ncbi.nlm.nih.gov/bioproject/PRJNA1475985 ↗
project · from NCBI GEO
- PubMed 42668625 pubmed.ncbi.nlm.nih.gov/42668625 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE334587 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |