Table 1_Comparative efficacy of intra-articular polynucleotide injection combined with rehabilitation therapy in knee osteoarthritis with and without diabetes mellitus and construction of a nomogram: a propensity score-matched cohort study.docx

Least absolute shrinkage and selection operator (LASSO) regression combined with multivariable Logistic regression was used to construct a nomogram predicting the probability of achieving Patient Acceptable Symptom State (PASS) at 6 months.</p>Results<p>After matching, no significant differences were observed between the two groups in the improvement trajectories of VAS and WOMAC scores (group effect, P > 0.05). Within the DM subgroup, the PASS achievement rate was significantly higher in patients with HbA1c < 7.0% than in those with HbA1c ≥ 7.0% (75.00% vs. 52.38%, P = 0.0248).

The nomogram identified rehabilitation adherence (odds ratio [OR] = 2.95, 95% CI: 1.62–5.40), whereas uncontrolled DM (HbA1c ≥ 7.0%; OR = 0.40, 95% CI: 0.22–0.78), KL grade IV (OR = 0.35, 95% CI: 0.18–0.70), and BMI ≥ 28 kg/m² (OR = 0.58, 95% CI: 0.35–0.96) were inversely associated with PASS achievement. The nomogram yielded a C-index of 0.82.</p>Conclusion<p>Among patients with KOA receiving intra-articular PN injection together with a prescribed rehabilitation program, those with T2DM showed 6-month clinical outcome trajectories comparable to those without DM.

Good glycemic control and favorable rehabilitation adherence are key factors for optimizing therapeutic outcomes.</p>