Table · dataset · 2026
Rapid On-Site Detection of Ginsenosides in Panax ginseng Using Portable Miniature Mass Spectrometry by Sodium Acetate-Enhanced Nanoelectrospray Ionization and a Same-Spectrum Same-Screening Quantification Strategy
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.1021/acsomega.6c07119.s001
Ginsenosides are the major bioactive constituents in Panax ginseng (PG), exhibiting diverse pharmacological effects, including anticancer, neuroprotective, cardioprotective, and anti-inflammatory activities.
Description
On-site mass spectrometry (MS) analysis of ginsenosides plays a crucial role in PG quality control. However, owing to matrix effects, structural complexity, low volatility, poor proton affinity, and the presence of multiple glycosidic moieties, rapid analysis of ginsenosides using portable MS under ambient conditions remains challenging.
Here, we developed a sodium acetate (NaOAc)-enhanced nanoelectrospray ionization (nESI) method enabling rapid, on-site ginsenoside profiling using miniature mass spectrometry (mMS). NaOAc-mediated cationization promotes efficient formation of [M + Na]<sup>+</sup> ions, enhancing ion signal intensity. Ginsenosides were detected using full-scan MS and MS/MS, including Rb1, Rg1, Re, Rd, Rf, notoginsenoside R1, etc.
Read the rest (2 more)
For quantitative analysis of the three pharmacopoeial markers (Rb1, Rg1, and Re), a same-spectrum and same-screening (4S) strategy using structurally similar saponins as an internal standard was established. The method exhibited good linearity (5–100 μg·mL<sup>–1</sup>, <i>R</i><sup>2</sup> > 0.99), acceptable precision (RSD < 13%), and recoveries. The limits of detection (LOD) for Rb1, Rg1, and Re were 0.10–0.20 μg·mL<sup>–1</sup>, respectively.
Application of the method to PG samples of different cultivation ages revealed that the Rb1/Re ratio strongly correlated with cultivation age. This work demonstrated a practical strategy to enhance ionization efficiency and quantitative robustness in mMS and provided a feasible approach for on-site chemical assessment of herb medicines.
Links
Where it is published
- DOI doi.org/10.1021/acsomega.6c07119.s001 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Astronomy & Astrophysics · Astronomy & Astrophysics · Astronomy & Astrophysics · Chemistry · Chemistry · Chemistry · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Ecology · Ecology · Ecology · Inorganic chemistry · Inorganic chemistry · Inorganic chemistry · Life Sciences · Life Sciences · Life Sciences · Medicine & Health · Medicine & Health · Medicine & Health · Microbiology · Microbiology · Microbiology
- Inferred from text
- Mass spectrometry 75%
Provenance · 3 source records, 30 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34040607 | 10 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/34040607 | 10 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/34040607 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:group:3103 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Ecology'] |
| concepts[field].anzsrc:group:3103 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Ecology'] |
| concepts[field].anzsrc:group:3103 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Ecology'] |
| concepts[field].anzsrc:group:3107 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3107 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3107 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3402 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Inorganic Chemistry'] |
| concepts[field].anzsrc:group:3402 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['Inorganic Chemistry'] |
| concepts[field].anzsrc:group:3402 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Inorganic Chemistry'] |
| concepts[field].local:field:astronomy | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:astronomy | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:astronomy | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[modality].local:modality:mass-spectrometry | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |