Omics · study · 2026
Synthetic facultative heterochromatin as a driver of evolvability
Listed in NCBI GEO
Description
Background
Epigenetic regulation has long been hypothesized to enhance evolvability by generating heritable, selectable phenotypic variation. However, experimental evidence linking chromatin-based mechanisms to adaptive evolution remains lacking, because endogenous epigenetic systems are deeply integrated into essential developmental and regulatory networks, making it nearly impossible to perturb or remove them. Here, we report construction of a minimal Polycomb group silencing system in Saccharomyces cerevisiae (yeast), an organism that naturally lacks H3K27me3-based heterochromatin.
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This synthetic epigenetic circuit enables programmable, locus-specific facultative heterochromatin formation and exhibits mitotically heritable gene silencing. Using this system, we show epigenetic repression generates transcriptional heterogeneity under stress, biasing phenotypic variation to accelerate the emergence and fixation of adaptive mutations. These findings establish a mechanistic link between facultative heterochromatin and enhanced evolvability, and provide a tractable platform for engineering and interrogating the evolutionary consequences of chromatin state dynamics.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307338 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307338 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1303337 ncbi.nlm.nih.gov/bioproject/PRJNA1303337 ↗
project · from NCBI GEO
Topics
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE307338 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:4932 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |