Data · dataset · 2026
<p>Sph deficiency attenuates <i>S. aureus</i>-induced mastitis and ferroptotic tissue injury in mice.</p>
Listed in ZivaHub
<p>Mice were intramammarily inoculated through mammary gland with 5 × 10⁶ CFU of <i>S. aureus</i> WT, Δ<i>sph</i>, or Δ<i>sph::sph</i> strains.
Description
Infected mice received deferiprone (50 mg/kg) or vehicle by oral gavage every 8 h for 48 h (n = 6 per group). <b>(A)</b> Gross morphology of mammary glands. <b>(B)</b> Representative H&E-stained sections of mammary tissues. Scale bars, 400 μm. <b>(C)</b> Bacterial burdens in mammary tissues. <b>(D, E)</b> TNF-α (D) and IL-6 (E) levels in mammary tissue homogenates. <b>(F)</b> GSH levels in mammary tissues. <b>(G)</b> MDA levels in mammary tissues. <b>(H)</b> MPO activity in mammary tissues. <b>(I)</b> Representative immunohistochemical staining of GPX4 in mammary tissues.
Scale bars, 400 μm. Data are presented as mean ± SD. *<i>P</i> < 0.05; **<i>P</i> < 0.01; ns, not significant.</p>
Links
Where it is published
- DOI doi.org/10.1371/journal.ppat.1014644.g007 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
Provenance · 1 source records, 15 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/34026606 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:field:310706 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Virology'] |
| concepts[field].anzsrc:field:320211 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Infectious Diseases'] |
| concepts[field].anzsrc:field:440710 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Science Policy'] |
| concepts[field].anzsrc:group:3101 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Cell Biology'] |
| concepts[field].anzsrc:group:3105 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Genetics'] |
| concepts[field].anzsrc:group:3107 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3204 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['Immunology'] |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/rights |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |