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Data · dataset · 2026

Feasibility and preliminary validation of the LIBRA model among those with mild TBI

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<p>Methods are needed to evaluate the influence of risk factors on post-injury brain health among those with mild traumatic brain injury (mTBI).

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We employed an existing model, the LIfestyle for BRAin Health (LIBRA), to demonstrate feasibility and establish initial validation with mTBI cohorts.</p> <p>Analyses of data from 17 civilians with acute mTBI (longitudinal) and 92 male United States Veterans with historical mTBI (cross-sectional).

LIBRA scores were constructed; a higher score indicates greater risk to brain health. We also evaluated score distributions, the prevalence of LIBRA factors, and associations with non-LIBRA risk factors (initial validation).</p> <p>Among those with acute mTBI (longitudinal), the mean ± standard deviation LIBRA score across all time points was 2.34 ± 3.19 (range −1.0 to +11.1). Individual scores were relatively stable across time, with some variability in physical activity and alcohol use.

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In Veterans with historical mTBI (cross-sectional), the mean LIBRA score was 3.92 ± 2.64 (range −1.0 to +10.3). The most prevalent risk factors were obesity and lifetime history of smoking followed by current depression. Initial validation findings were mixed.</p> <p>Differences in LIBRA scores and other drivers of risk (non-LIBRA) across two mTBI cohorts (acute, historical) support the feasibility of implementation among those with a history of mTBI.</p>

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Longitudinal study 65%
Provenance · 1 source records, 13 field assertions
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