<p>Protein-level evidence integration and prioritization of shared OA-OP candidates.</p>

<p>(A) Integrated ranking of the top 15 proteins according to the composite priority score, with the three highest-ranked proteins highlighted. (B) Profiles of the six normalized evidence dimensions for the top 10 proteins. Values correspond to those reported in <a href="plosone.org/article/info:doi/10.1371/journal.pone.0359583#pone.0359583.t002" target="_blank">Table 2</a>, and right-side labels identify the largest evidence dimension for each protein.

(C) OmniPath neighborhood of the leading proteins. Colored nodes indicate prioritized proteins, gray nodes indicate shared connector genes, and directed edges indicate curated signaling relationships. (D) Genetic-evidence and protein-feasibility profiles of the leading proteins.