Omics · study · 2026
Transcriptomic changes in Grin2b-C456Y-mutant mice with NMDAR activation
Listed in NCBI GEO
Description
Our previous study reported a Grin2b-mutant mouse line carrying a point mutation identified in individuals with ASD (Grin2b+/C456Y mice), which show suppressed long-term depression and anxiolytic-like behavior that are responsive to early chronic D-cycloserine (DCS) treatment (postnatal day 7 to 16) for pharmacological activation of NMDARs. To figure out the rescue mechanism, we attempted RNA-Seq analysis of wild-type (WT) and Grin2b+/C456Y mice that are early and chronically treated with vehicle and DCS.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE237nnn/GSE237027 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE237027 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA993566 ncbi.nlm.nih.gov/bioproject/PRJNA993566 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE237027 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |