Data · dataset · 2026
Development and evaluation of infection-resistant coatings for medical devices
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32640462.v1
Healthcare-associated infections are a significant concern, leading to surgical failures, increased patient mortality, and higher healthcare costs.
Description
These infections primarily result from bacterial invasion and biofilm formation on device surfaces. This research aims to develop, characterize, and compare antibacterial hydrogels to combat such infections.
Two types of hydrogels were fabricated: antibacterial agent-releasing hydrogels and contact-killing hydrogels. Cationic surfactants, benzalkonium chloride (BAK) and didecyldimethylammonium bromide (DDAB), were incorporated into acrylate-based hydrogels to target S. aureus and E. coli. Additionally, 1-vinyl-3-imidazolium bromide was used to create contact-active hydrogels against S. aureus and P. aeruginosa.HEMA copolymers with methyl methacrylate (MMA) and methacrylic acid (MAA) were synthesized to study their hydrophilicity, water uptake, and drug release profiles using fluorescein sodium (FS).
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The p(85% HEMA-co-15% MAA) hydrogels showed increased hydrophilicity and pH-sensitive swelling, suitable for urological applications, while p(85% HEMA-co-15% MMA) demonstrated slower drug release rates.BAK and DDAB showed strong bactericidal effects but were cytotoxic at certain concentrations. To mitigate this, VBIM was incorporated into hydrogels, resulting in surfaces with strong anti-adherent properties and excellent cytocompatibility.
VBIM-based hydrogels applied as PVC coatings exhibited enhanced hydrophilicity and significant bacterial resistance but were less effective in the presence of protein adsorption. This research underscores the potential of antibacterial hydrogels in preventing device-associated infections, suggesting future work to optimize their clinical application by balancing antimicrobial efficacy, cytocompatibility, and protein resistance.<br><i><br>Thesis embargoed until 31st December 2029</i>
Links
Where it is published
- DOI doi.org/10.17034/32640462.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
Provenance · 3 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32640462 | 12 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32640462 | 12 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32640462 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |