Sputnik V Vaccine Elicits Seroconversion and Neutralizing Capacity to SARS CoV-2 after a Single Dose - Dataset

However, limited supply and uneven vaccine distribution create an urgent need to optimize vaccination strategies. We evaluated SARS CoV-2-specific antibody responses after Sputnik V vaccination of 206,000 healthcare workers in Buenos Aires, Argentina, measuring IgG anti-spike antibody titers and virus neutralizing capacity after one and two doses in a cohort of naïve or previously infected volunteers (N=288).

By 21 days after receiving the first dose of vaccine, 94% of naïve participants had developed spike-specific IgG antibodies (96% and 89% of participants <60 and >60 years old, respectively), whereas 100% of participants had acquired spike-specific antibodies by 21 days after receiving a second vaccine dose. A single Sputnik V dose elicited higher spike-specific antibody levels and virus neutralizing capacity in previously infected individuals than in individuals without prior infection receiving the full two-dose schedule.