Resveratrol in depression: mechanistic networks, preclinical evidence and translational perspectives

This review evaluates mechanistic, preclinical, human and translational evidence for resveratrol in depression.</p> <p> We conducted a structured narrative review of English-language literature to 30 June 2026 using PubMed, Web of Science Core Collection, Scopus and ScienceDirect, supplemented by Google Scholar and citation searching.

After duplicate removal, 4,461 records were screened, 142 full texts assessed and 71 publications included.</p> <p>Antidepressant-like effects were reported across stress, endocrine, developmental, post-stroke, metabolic and gut-inflammatory models, involving SIRT1/AMPK, NF-κB/ NLRP3, Nrf2/HO-1, mitochondrial and ferroptosis pathways,monoaminergic and cAMP/PKA/CREB/BDNF signalling, and gut brain communication. However, many studies used preventive or concurrent dosing, male animals, high doses or non-oral routes.