RNA-seq analysis of rat liver under drug treatment

This study demonstrates that EF induces significant liver injury only under conditions of immune stress, characterized by a pro-inflammatory and metabolically vulnerable hepatic state. Importantly, herb compatibility critically modulates this risk.

Co-administration of Psoraleae Fructus (PF) markedly exacerbated EF-induced hepatotoxicity through amplification of inflammatory and cell death–related pathways, whereas Rhizoma Drynariae (RD) partially attenuated liver injury by stabilizing cholesterol and bile acid metabolism and restoring hepatic homeostasis