Omics · study · 2026
The role of gliovascular crosstalk between vascular pathology and Alzheimer’s disease
Listed in NCBI GEO
Alzheimer's disease (AD) frequently occurs alongside cerebrovascular pathology (CVP), which together exacerbate cognitive decline and dementia.
Description
Gaining insights into the molecular interactions between these conditions is crucial for creating effective treatments that can tackle the complexities of AD. To determine impact of gliovascular interactions on the blood-brain-barrier (BBB) experimentally, we utilized a well-established zebrafish model.We treated double transgenic (Tg(fli1a:eGFP)/Tg(her4.1:dRFP)) zebrafish with vegf receptor inhibitor cocktails to evaluate the BBB integrity.
By blocking VEGF signaling we showed that astroglial-endothelial interactions are essential for BBB integrity.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE269nnn/GSE269111 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE269111 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1120335 ncbi.nlm.nih.gov/bioproject/PRJNA1120335 ↗
project · from NCBI GEO
Topics
- Stated by source
- Danio rerio · Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE269111 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:7955 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |