Iron Status and Cardiac Conduction in Humans: Aggregate Data and Analysis Code for a Systematic Review

It provides aggregate data extracted from published reports and Python code for reproducing individual-study estimates, sensitivity analyses, exploratory syntheses, and figures. The review examines iron deficiency, iron-deficiency anemia, systemic iron overload, and myocardial iron burden in relation to PR interval, QRS duration, atrioventricular block, and supporting electrophysiological measures.

Evidence is organized by population, iron exposure, clinical setting, outcome, and comparison type to distinguish disease-status associations, within-disease iron comparisons, and treatment-related changes. The package includes: • A bibliography and clinical characteristics of 44 quantitative-candidate reports. • Extracted statistical inputs and 52 display results from 15 reports, comprising 47 results with usable comparative confidence intervals, three conditional results, and two descriptive results. • Six paired-correlation sensitivity records, 13 supplementary evidence records, and four explicitly post hoc exploratory pooling scenarios. • Preliminary outcome-specific risk-of-bias and evidence-certainty assessments. • Offline Python scripts, dependency specifications, data documentation, numerical verification outputs, and editable SVG figures.