Data from: Changes in alternative splicing are associated with insecticide response and resistance

Instead, the specific classes of genes that are differentially spliced are better determinants of insecticide resistance. Furthermore, we observe that sublethal insecticide exposure promotes AS events even in the absence of substantial differential gene expression. Our proposed model underlying the development of insecticide resistance in <em>D. suzukii</em> aligns with the genetic accommodation framework, in which repeated insecticide exposure alters the regulation of environmentally induced AS events, ultimately leading to genetic assimilation.

This leads to elevated AS of specific transcripts, a phenomenon normally induced by insecticide exposure, becoming genetically encoded and constitutively expressed, even in the absence of insecticide exposure. In summary, this study provides insights into the role of AS in enabling insects to diversify genome function to survive acute insecticide treatment and to develop xenobiotic resistance upon prolonged exposure.</p>