Omics · study · 2026
Effect of brain-derived EV from PS19 and PS19_P2rx7 knockout mice on gene expression in microglia from WT mice
Listed in NCBI GEO
P2rx7 is an ATP-gated ion-channel, known to play pivotal roles in neuroinflammation and tauopathies, although its mechanisms are yet to be elucidated.
Description
In this study we investigated the effect of intracranial injection of brain-derived EVs (BDEVs) from P2rx7 deficient tauopathy mouse in microglia transcriptomics. This dataset is part of BioProject PRJNA1281629, which includes bulk and single-cell RNAseq experiments.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301093 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301093 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1281629 ncbi.nlm.nih.gov/bioproject/PRJNA1281629 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE301093 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |