Text · study · 2026
Antibodies derived from patient tumors augment response to immune checkpoint blockade in cancer
Listed in NCBI GEO
B-cells are associated with favorable response to immunotherapy, though the underlying mechanisms remain unclear.
Description
Here, we profiled tumor-infiltrating B-cells (TIL-Bs) and tertiary lymphoid structures (TLS) from α-PD-1 + α-CTLA-4 treated responders (R) and non-responders (NR) to identify immune signatures. TLS from responders exhibited upregulated inflammatory genes, and increased levels of cytotoxic immune cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE331nnn/GSE331322 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE331322 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1467675 ncbi.nlm.nih.gov/bioproject/PRJNA1467675 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Other
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE331322 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |