Omics · study · 2026
Genome-wide DNA Methylation Profiling in Postpartum Depression: A Longitudinal Whole-Blood Study
Listed in NCBI GEO
This dataset contains genome-wide DNA methylation data derived from whole human blood samples collected from postpartum women enrolled in a longitudinal cohort study (2018–2023, N = 827).
Description
Blood samples were drawn within 6 days of delivery (t0) and at 12 weeks postpartum (t4). Participants were assessed longitudinally for postnatal depression (EPDS), perceived stress (PSS-10), and mother-infant attachment (MPAS).
A subset of N = 247 participants with complete blood sampling was used for methylation analysis; mothers with the most severe depressive symptoms (PPD group, n = 17, DSM-5 confirmed) were compared to a euthymic healthy control group (HC, n = 24). Genome-wide methylation profiling was performed using the Illumina Infinium Human MethylationEPICv2 BeadChip. Differential methylation analysis was conducted using the ChAMP package (BMIQ normalization, limma-based DMP calling).
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The goal of this study is to identify epigenetic signatures associated with postpartum depression.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE335nnn/GSE335141 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE335141 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1477462 ncbi.nlm.nih.gov/bioproject/PRJNA1477462 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Methylation profiling by genome tiling array
- From keywords
- Life Sciences
- Inferred from text
- DNA methylation profiling 75% · Longitudinal study 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE335141 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-genome-tiling-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].local:method:dna-methylation-profiling | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[method].local:method:longitudinal-study | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |