Omics · study · 2026
RNA-seq profiling of L4-stage Caenorhabditis elegans exposed to AO168=O at environmentally relevant concentrations
Listed in NCBI GEO
Tris(2,4-di-tert-butylphenyl) phosphate (AO168=O) is an emerging organophosphate contaminant derived from plastic antioxidants and widely detected in soils.
Description
To investigate its chronic biological effects, synchronized Caenorhabditis elegans were exposed to AO168=O in agar-based NGM medium and sampled at the L4 stage for transcriptomic analysis. Bulk RNA-seq was performed on control and AO168=O-treated worms at 400, 2000, and 10000 ng/g, with three biological replicates per group.
The dataset was generated to characterize transcriptional responses associated with developmental restriction and IIS/DAF-16-related stress-responsive pathways.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329157 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329157 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1458061 ncbi.nlm.nih.gov/bioproject/PRJNA1458061 ↗
project · from NCBI GEO
- PubMed 42313644 pubmed.ncbi.nlm.nih.gov/42313644 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Caenorhabditis elegans · Expression profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE329157 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:6239 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |