Omics · study · 2026
CITE-seq of circulating CD4+ T cells and monocytes from BMT recipients treated with or without Tocilizumab
Listed in NCBI GEO
Allogeneic hematopoietic stem cell transplantation (SCT) is a curative treatment for hematological cancers but outcomes are limited by graft-versus-host disease (GVHD).
Description
IL-6R expression and IL-6 signaling are most pronounced in CD4 T cells and monocytesand promote acute GVHD (aGVHD) in preclinical models by inducing Th17 and Th22 differentiation. To understand the effect of IL-6 signaling on T cell responses in humans, we performed CITE-seq on circulating CD14+ monocytes and CD4+ T cells from HSCT recipients in a randomized controlled clinical trial receiving tocilizumab (TCZ) or placebo who did not develop acute GVHD.
A third placebo treated group were analyzed prior to their development of aGVHD. IL-6 inhibition promoted Type I IFN-associated transcriptional programs in both CD4+ T cells and CD14+ monocytes relative to those from placebo-treated recipients
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE304nnn/GSE304894 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE304894 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1303188 ncbi.nlm.nih.gov/bioproject/PRJNA1303188 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens · Other
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE304894 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |