Table · dataset · 2026
Health benefits and physiological actions of micronutrients, probiotics/prebiotics, phytochemicals, and their associated deficiency diseases: a systematic review of recent developments and applications
Listed in DMU Figshare and UCL Research Data Repository and HKU DataHub and Swinburne Figshare and DaYta Ya Rona and SUNScholarData and figshare and Loughborough Research Repository and GRANTS Data and UP Research Data Repository — shown once because both records carry DOI 10.6084/m9.figshare.34048468.v1
<p>Micronutrients, probiotics/prebiotics, and phytochemicals influence physiological function, but benefits vary by baseline nutritional status, intervention, population, and outcome.
Description
This systematic review synthesizes evidence from primary research and high-quality reviews (2016–2026) on vitamins/minerals, probiotics/prebiotics, phytochemicals, and deficiency- or dysbiosis-related conditions. Following PRISMA 2020, searches covered PubMed/PMC, Scopus, ScienceDirect, Web of Science, Wiley Online Library, Taylor & Francis Online, MDPI, Frontiers, SAGE, Google Scholar, and WHO/FAO resources.
Widespread micronutrient inadequacies were identified, particularly for iron, iodine, calcium, and vitamin E. Intervention evidence was strongest for correcting established deficiencies and selected strain- or outcome-specific probiotic applications. Evidence for extra-skeletal vitamin D effects, broad cardiometabolic prevention, phytochemical supplementation, and microbiome-mediated nutrient benefits was more heterogeneous and often observational or mechanistic rather than definitive clinical trials.
Read the rest (2 more)
Heterogeneity in populations, doses, formulations, comparators, outcomes, and designs precluded quantitative pooling; conclusions were therefore synthesized narratively according to evidence type and risk of bias. Evidence supports food-based dietary adequacy, targeted fortification/supplementation for demonstrated or high-risk deficiency, and cautious use of selected probiotics/prebiotics where strain- and outcome-specific evidence exists.
Precision nutrition, biomarker-guided strategies, and microbiome-informed interventions remain insufficiently validated for population-wide implementation. More studies should prioritize adequately powered, long-term, preregistered trials with clinically meaningful outcomes and standardized reporting.</p>
Links
Where it is published
- DOI doi.org/10.6084/m9.figshare.34048468.v1 ↗
DOI / persistent id · from figshare dmu ac uk
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from figshare dmu ac uk
Topics
- From keywords
- Astronomy & Astrophysics · Cancer · Cancer · Cancer · Cancer · Cancer · Cancer · Cancer · Cancer · Cancer · Cancer · Chemistry · Chemistry · Chemistry · Chemistry · Chemistry · Chemistry · Chemistry · Chemistry · Chemistry · Chemistry · Clinical nutrition · Clinical nutrition · Clinical nutrition · Clinical nutrition · Clinical nutrition · Clinical nutrition · Clinical nutrition · Clinical nutrition · Clinical nutrition · Clinical nutrition · Computer Science & AI · Computer Science & AI · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Economics & Finance · Economics & Finance · Engineering · Engineering · Engineering · Engineering · Humanities · Humanities · Humanities · Humanities · Life Sciences · Life Sciences · Life Sciences · Life Sciences · Life Sciences · Life Sciences · Life Sciences · Life Sciences · Life Sciences · Life Sciences · Materials Science · Mathematics & Statistics · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health · Medicine & Health · Microbiology · Microbiology · Microbiology · Microbiology · Microbiology · Microbiology · Microbiology · Microbiology · Microbiology · Microbiology · Nutrition and dietetics · Nutrition and dietetics · Nutrition and dietetics · Nutrition and dietetics · Nutrition and dietetics · Nutrition and dietetics · Nutrition and dietetics · Nutrition and dietetics · Nutrition and dietetics · Nutrition and dietetics · Ocean & Atmospheric Science · Psychology & Behavioral Science · Social Science · Social Science · Social Science · Social Science · Social Science · Social Science · Social Science · Social Science · Social Science · Social Science · Sociology · Sociology · Sociology · Sociology · Sociology · Sociology · Sociology · Sociology · Sociology · Sociology
Provenance · 10 source records, 122 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| DMU Figshare | oai:figshare.com:article/34048468 | 5 d ago | JSON v1 |
| UCL Research Data Repository | oai:figshare.com:article/34048468 | 5 d ago | JSON v1 |
| HKU DataHub | oai:figshare.com:article/34048468 | 4 d ago | JSON v1 |
| Swinburne Figshare | oai:figshare.com:article/34048468 | 4 d ago | JSON v1 |
| DaYta Ya Rona | oai:figshare.com:article/34048468 | 4 d ago | JSON v1 |
| SUNScholarData | oai:figshare.com:article/34048468 | 4 d ago | JSON v1 |
| figshare | oai:figshare.com:article/34048468 | 4 d ago | JSON v1 |
| Loughborough Research Repository | oai:figshare.com:article/34048468 | 3 d ago | JSON v1 |
| GRANTS Data | oai:figshare.com:article/34048468 | 3 d ago | JSON v1 |
| UP Research Data Repository | oai:figshare.com:article/34048468 | 3 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[disease].local:disease:cancer | mapping · scholardata sun ac za | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · dayta nwu ac za | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · grantsdata jst go jp | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · figshare swinburne edu au | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[disease].local:disease:cancer | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Cancer'] |
| concepts[field].anzsrc:field:321001 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Clinical Nutrition'] |
| concepts[field].anzsrc:field:321001 | mapping · scholardata sun ac za | vocabulary-mapper@1.0.0 | keywords['Clinical Nutrition'] |
| concepts[field].anzsrc:field:321001 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Clinical Nutrition'] |
| concepts[field].anzsrc:field:321001 | mapping · grantsdata jst go jp | vocabulary-mapper@1.0.0 | keywords['Clinical Nutrition'] |
| concepts[field].anzsrc:field:321001 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Clinical Nutrition'] |
| concepts[field].anzsrc:field:321001 | mapping · figshare swinburne edu au | vocabulary-mapper@1.0.0 | keywords['Clinical Nutrition'] |
| concepts[field].anzsrc:field:321001 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Clinical Nutrition'] |
| concepts[field].anzsrc:field:321001 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Clinical Nutrition'] |
| concepts[field].anzsrc:field:321001 | mapping · dayta nwu ac za | vocabulary-mapper@1.0.0 | keywords['Clinical Nutrition'] |
| concepts[field].anzsrc:field:321001 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Clinical Nutrition'] |
| concepts[field].anzsrc:group:3107 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3107 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3107 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3107 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3107 | mapping · grantsdata jst go jp | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3107 | mapping · dayta nwu ac za | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3107 | mapping · scholardata sun ac za | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3107 | mapping · figshare swinburne edu au | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3107 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3107 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Microbiology'] |
| concepts[field].anzsrc:group:3210 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Nutrition and Dietetics'] |
| concepts[field].anzsrc:group:3210 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Nutrition and Dietetics'] |
| concepts[field].anzsrc:group:3210 | mapping · grantsdata jst go jp | vocabulary-mapper@1.0.0 | keywords['Nutrition and Dietetics'] |
| concepts[field].anzsrc:group:3210 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Nutrition and Dietetics'] |
| concepts[field].anzsrc:group:3210 | mapping · scholardata sun ac za | vocabulary-mapper@1.0.0 | keywords['Nutrition and Dietetics'] |
| concepts[field].anzsrc:group:3210 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Nutrition and Dietetics'] |
| concepts[field].anzsrc:group:3210 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Nutrition and Dietetics'] |
| concepts[field].anzsrc:group:3210 | mapping · figshare swinburne edu au | vocabulary-mapper@1.0.0 | keywords['Nutrition and Dietetics'] |
| concepts[field].anzsrc:group:3210 | mapping · dayta nwu ac za | vocabulary-mapper@1.0.0 | keywords['Nutrition and Dietetics'] |
| concepts[field].anzsrc:group:3210 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Nutrition and Dietetics'] |
| concepts[field].anzsrc:group:4410 | mapping · figshare swinburne edu au | vocabulary-mapper@1.0.0 | keywords['Sociology'] |
| concepts[field].anzsrc:group:4410 | mapping · grantsdata jst go jp | vocabulary-mapper@1.0.0 | keywords['Sociology'] |
| concepts[field].anzsrc:group:4410 | mapping · rdr ucl ac uk | vocabulary-mapper@1.0.0 | keywords['Sociology'] |
| concepts[field].anzsrc:group:4410 | mapping · repository lboro ac uk | vocabulary-mapper@1.0.0 | keywords['Sociology'] |
| concepts[field].anzsrc:group:4410 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['Sociology'] |
| concepts[field].anzsrc:group:4410 | mapping · dayta nwu ac za | vocabulary-mapper@1.0.0 | keywords['Sociology'] |
| concepts[field].anzsrc:group:4410 | mapping · scholardata sun ac za | vocabulary-mapper@1.0.0 | keywords['Sociology'] |
| concepts[field].anzsrc:group:4410 | mapping · researchdata up ac za | vocabulary-mapper@1.0.0 | keywords['Sociology'] |
| concepts[field].anzsrc:group:4410 | mapping · figshare com | vocabulary-mapper@1.0.0 | keywords['Sociology'] |
| concepts[field].anzsrc:group:4410 | mapping · datahub hku hk | vocabulary-mapper@1.0.0 | keywords['Sociology'] |
| concepts[field].local:field:astronomy | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare swinburne edu au | connector:figshare_swinburne_edu_au@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · scholardata sun ac za | connector:scholardata_sun_ac_za@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · grantsdata jst go jp | connector:grantsdata_jst_go_jp@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:chemistry | mapping · dayta nwu ac za | connector:dayta_nwu_ac_za@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:computer-science-ai | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare swinburne edu au | connector:figshare_swinburne_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dayta nwu ac za | connector:dayta_nwu_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · scholardata sun ac za | connector:scholardata_sun_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · grantsdata jst go jp | connector:grantsdata_jst_go_jp@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:economics-finance | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:engineering | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:engineering | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:engineering | mapping · dayta nwu ac za | connector:dayta_nwu_ac_za@1.0.0 | |
| concepts[field].local:field:humanities | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:humanities | mapping · dayta nwu ac za | connector:dayta_nwu_ac_za@1.0.0 | |
| concepts[field].local:field:humanities | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:humanities | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dayta nwu ac za | connector:dayta_nwu_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scholardata sun ac za | connector:scholardata_sun_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare swinburne edu au | connector:figshare_swinburne_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · grantsdata jst go jp | connector:grantsdata_jst_go_jp@1.0.0 | |
| concepts[field].local:field:materials-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:mathematics-statistics | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · scholardata sun ac za | connector:scholardata_sun_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dayta nwu ac za | connector:dayta_nwu_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare swinburne edu au | connector:figshare_swinburne_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · grantsdata jst go jp | connector:grantsdata_jst_go_jp@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:ocean-atmospheric | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:psychology-behavioral | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scholardata sun ac za | connector:scholardata_sun_ac_za@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare com | connector:figshare_com@1.0.0 | |
| concepts[field].local:field:social-science | mapping · researchdata up ac za | connector:researchdata_up_ac_za@1.0.0 | |
| concepts[field].local:field:social-science | mapping · dayta nwu ac za | connector:dayta_nwu_ac_za@1.0.0 | |
| concepts[field].local:field:social-science | mapping · rdr ucl ac uk | connector:rdr_ucl_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · repository lboro ac uk | connector:repository_lboro_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · grantsdata jst go jp | connector:grantsdata_jst_go_jp@1.0.0 | |
| concepts[field].local:field:social-science | mapping · datahub hku hk | connector:datahub_hku_hk@1.0.0 | |
| concepts[field].local:field:social-science | mapping · figshare swinburne edu au | connector:figshare_swinburne_edu_au@1.0.0 | |
| description | source · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | /metadata/dc/description |
| license | source · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | /metadata/dc/rights |
| publication_date | source · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| title | source · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | /metadata/dc/title |