Data · dataset · 2026
Single-Cell Morpho-Electric Dataset of Mouse PVN Oxytocin Neurons Across Sex, Anatomical Axis, and Feeding States
Listed in ScienceDB
Oxytocin (OXT) neurons in the paraventricular nucleus of the hypothalamus (PVN) play critical roles in neuroendocrine regulation and diverse behaviors, including feeding, social interaction, maternal care, and emotional processing.
Description
Although these neurons are conventionally classified as magnocellular (Magno-OXTn) or parvocellular (Parvo-OXTn), this binary framework insufficiently captures their true heterogeneity, and integrative datasets at the single-cell level remain scarce.
To address this gap, we generated a curated morpho‑electric dataset of mouse PVN OXT neurons using adult Oxt-Cre; Ai3 mice of both sexes. The dataset comprises whole-cell patch-clamp recordings from 224 PVNOXT neurons obtained across fed, fasted, and refed conditions (10 males and 13 females). For 213 neurons of these neurons, we also provide biocytin-based morphological reconstructions and atlas-registered spatial annotations.
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In total, the release includes 29 electrophysiological and morphological features per cell, along with comprehensive metadata covering sex, feeding status, cell type, rostrocaudal position, PVN subdivision, quality control metrics, and subtype labels. Additionally, we supply a clustering-ready matrix for 203 neurons with complete data, as well as custom analysis scripts. This resource supports reproducible investigations of OXT neuron diversity, facilitates computational modeling, enables cross-sex and cross-state comparisons, and allows integration with transcriptomic or multimodal datasets.
The accompanying Data Paper details the experimental procedures, metadata schema, validation strategies, and recommended reuse practices, thereby providing a robust foundation for future studies of hypothalamic circuitry and oxytocin system function.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.nb.00050 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Social Science
- Inferred from text
- Zoology 72%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.nb.00050 | 12 d ago | JSON v1 |
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|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
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| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |