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There is an urgent to develop an effective subunit vaccine against TGEV to control the spread of the disease. Viral antigens, spike glycoprotein (S), is one of the most ideal antigenic components for vaccine design.

In this study, we used immunoinformatic approaches, together with molecular dynamics analysis, to predict the dominant non-toxicity and high antigenicity Th, CTL, and B cell epitopes derived from S protein and design a multi-epitope subunit vaccine. The results show that the designed TGEV vaccine was non-toxicity, high immunogenicity, stable, and cost-effective. The molecular docking and dynamic simulations reveal that the designed vaccine has the stable interaction with TLR4.