Omics · study · 2026
Hyperploidy is the intermediate state of hepatocyte transforming into ICC
Listed in NCBI GEO
Polyploid cells frequently appear in tumor tissues, but it is not yet conclusively determined whether polyploid cells promote or inhibit tumor development.
Description
In this study, we combine two characteristics of hepatocytes—polyploidy and high plasticity—to investigate the role of polyploidy in the transdifferentiation of hepatocytes into precursor cells, as well as its role and mechanism in the further development of intrahepatic cholangiocarcinoma.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE276nnn/GSE276342 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE276342 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1156750 ncbi.nlm.nih.gov/bioproject/PRJNA1156750 ↗
project · from NCBI GEO
- PubMed 40489743 pubmed.ncbi.nlm.nih.gov/40489743 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE276342 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |